Despite progress in the development of anti-seizure drugs, drug-resistant epilepsy (DRE)
occurs in a third of patients. DRE is associated with poor quality of life and increased risk of …

Mutations in SCN1A, the gene encoding voltage-gated sodium channel NaV1. 1, cause a
spectrum of epilepsy disorders that range from genetic epilepsy with febrile seizures plus to …

A recurring target-site mutation identified in various pests and disease vectors alters the
voltage gated sodium channel (vgsc) gene (often referred to as knockdown resistance or …

The idea that alterations in gut-microbiome-brain axis (GUMBA)-mediated communication
play a crucial role in human brain disorders like autism remains a topic of intensive research …

Epilepsy is one of the most common neurologic disorders. Around one third of patients do
not respond to current medications. This lack of treatment indicates a need for better …

Epilepsy is one of the most prevalent neurological disorders, affecting more than 45 million
people worldwide. Recent advances in genetic techniques, such as next-generation …

Sleep latency, the amount of time that it takes an individual to fall asleep, is a key indicator of
sleep need. Sleep latency varies considerably both among and within species and is …

Sleep loss has been associated with increased seizure risk since antiquity. Despite this
observation standing the test of time, how poor sleep drives susceptibility to seizures …

Kohlschütter-Tönz syndrome (KTS) manifests as neurological dysfunctions, including early-
onset seizures. Mutations in the citrate transporter SLC13A5 are associated with KTS, yet …

Ion channels are integral components of the nervous system, playing a pivotal role in
shaping membrane potential, neuronal excitability, synaptic transmission and plasticity …