Abstract Interleukin-10 (IL-10) is arguably the most potent anti-inflammatory cytokine. It is
produced by almost all the innate and adaptive immune cells. These cells also serve as its …

Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …

To assess the importance of B cell control of T cell differentiation, we analyzed the course of
the T helper type 1 (TH1)-driven disease experimental autoimmune encephalomyelitis in …

CD4+ effector T cells have been categorized into two subsets: T helper type 1 (TH1) and
TH2. Another subset of T cells that produce interleukin 17 (IL-17;'TH-17 cells') has been …

Microglia form a regularly spaced network of resident glial cells throughout the central
nervous system (CNS). They are morphologically, immunophenotypically and functionally …

In view of disease heterogeneity of multiple sclerosis and limited access to ex vivo
specimens, different approaches must be undertaken to better understand disease …

Experimental autoimmune encephalomyelitis (EAE) is a cell-mediated autoimmune disease
that serves as an animal model for multiple sclerosis. Oral administration of myelin basic …

Cyclooxygenase (COX) catalyses the first committed step in the synthesis of prostanoids, a
large family of arachidonic acid metabolites comprising prostaglandins, prostacyclin, and …

Background Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the
central nervous system (CNS). One potential therapeutic strategy for MS is to induce …

Multiple sclerosis (MS) is a T cell-dependent chronic inflammatory disease of the central
nervous system. The role of chemokines in MS and its different stages is uncertain. Recent …