Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

Methionine adenosyltransferase 2A (MAT2A) is a rate-limiting enzyme in the methionine
cycle that primarily catalyzes the synthesis of S-adenosylmethionine (SAM) from methionine …

Availability of the essential amino acid methionine affects cellular metabolism and growth,
and dietary methionine restriction has been implicated as a cancer therapeutic strategy …

Targeting altered tumor cell metabolism might provide an attractive opportunity for patients
with acute myeloid leukemia (AML). An amino acid dropout screen on primary leukemic …

Cancer cells are addictive to exogenous methionine to gear toward tumor proliferation.
Meanwhile, they can replenish methionine pool from polyamine metabolism through a …

Recent discoveries in cancer metabolism have revealed promising metabolic targets to
modulate cancer progression, drug response, and anti-cancer immunity. Combination …

Recent insights into histopathological and molecular subgroups of glioma have
revolutionized the field of neuro-oncology by refining diagnostic categories. An emblematic …

Bacterial‐mediated synergistic cancer therapy (BMSCT) is used as a promising tumor
therapy approach. However, there are some disadvantages of bacterial therapy alone to be …

Reprogramming of methionine metabolism is a conserved hallmark of tumorigenesis.
Recent studies have revealed mechanisms regulating methionine metabolism within the …

Background/Aim: Gliomas are the most common and recalcitrant malignant primary brain
tumors. All cancer types are addicted to methionine, which is a fundamental and general …