β-Barrel membrane protein assembly by the Bam complex

CL Hagan, TJ Silhavy, D Kahne - Annual review of biochemistry, 2011 - annualreviews.org
β-barrel membrane proteins perform important functions in the outer membranes (OMs) of
Gram-negative bacteria and of the mitochondria and chloroplasts of eukaryotes. The protein …

Membrane protein architects: the role of the BAM complex in outer membrane protein assembly

TJ Knowles, A Scott-Tucker, M Overduin… - Nature Reviews …, 2009 - nature.com
The folding of transmembrane proteins into the outer membrane presents formidable
challenges to Gram-negative bacteria. These proteins must migrate from the cytoplasm …

Peptidoglycan maturation controls outer membrane protein assembly

G Mamou, F Corona, R Cohen-Khait, NG Housden… - Nature, 2022 - nature.com
Linkages between the outer membrane of Gram-negative bacteria and the peptidoglycan
layer are crucial for the maintenance of cellular integrity and enable survival in challenging …

Structural insight into the biogenesis of β-barrel membrane proteins

N Noinaj, AJ Kuszak, JC Gumbart, P Lukacik, H Chang… - Nature, 2013 - nature.com
Abstract β-barrel membrane proteins are essential for nutrient import, signalling, motility and
survival. In Gram-negative bacteria, the β-barrel assembly machinery (BAM) complex is …

Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins

L Han, J Zheng, Y Wang, X Yang, Y Liu… - Nature structural & …, 2016 - nature.com
In Gram-negative bacteria, the assembly of β-barrel outer-membrane proteins (OMPs)
requires the β-barrel–assembly machinery (BAM) complex. We determined the crystal …

Lateral opening and exit pore formation are required for BamA function

N Noinaj, AJ Kuszak, C Balusek, JC Gumbart… - Structure, 2014 - cell.com
The outer membrane of Gram-negative bacteria is replete with a host of β-barrel outer
membrane proteins (OMPs). Despite serving a variety of essential functions, including …

Membrane protein insertion through a mitochondrial β-barrel gate

AIC Höhr, C Lindau, C Wirth, J Qiu, DA Stroud, S Kutik… - Science, 2018 - science.org
INTRODUCTION The outer membranes of Gram-negative bacteria, mitochondria, and
chloroplasts characteristically contain β-barrel membrane proteins. These proteins contain …

From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis

DL Leyton, AE Rossiter, IR Henderson - Nature Reviews Microbiology, 2012 - nature.com
Autotransporters are a superfamily of proteins that use the type V secretion pathway for their
delivery to the surface of Gram-negative bacteria. At first glance, autotransporters look to …

Discovery of an archetypal protein transport system in bacterial outer membranes

J Selkrig, K Mosbahi, CT Webb, MJ Belousoff… - Nature structural & …, 2012 - nature.com
Bacteria have mechanisms to export proteins for diverse purposes, including colonization of
hosts and pathogenesis. A small number of archetypal bacterial secretion machines have …

Outer membrane β-barrel protein folding is physically controlled by periplasmic lipid head groups and BamA

D Gessmann, YH Chung, EJ Danoff… - Proceedings of the …, 2014 - National Acad Sciences
Outer membrane β-barrel proteins (OMPs) are crucial for numerous cellular processes in
prokaryotes and eukaryotes. Despite extensive studies on OMP biogenesis, it is unclear why …