Emerging tumor-on-chips with electrochemical biosensors
Cancer, one of the most dangerous diseases with a high mortality rate, has attracted much
attention and interest. Advances in tissue engineering and microfluidics have led to the …
attention and interest. Advances in tissue engineering and microfluidics have led to the …
Recent methods of droplet microfluidics and their applications in spheroids and organoids
Y Wang, M Liu, Y Zhang, H Liu, L Han - Lab on a Chip, 2023 - pubs.rsc.org
Droplet microfluidic techniques have long been known as a high-throughput approach for
cell manipulation. The capacity to compartmentalize cells into picolitre droplets in …
cell manipulation. The capacity to compartmentalize cells into picolitre droplets in …
Spheroid engineering in microfluidic devices
Two-dimensional (2D) cell culture techniques are commonly employed to investigate
biophysical and biochemical cellular responses. However, these culture methods, having …
biophysical and biochemical cellular responses. However, these culture methods, having …
Multidimensional controllable fabrication of tumor spheroids based on a microfluidic device
Y Hou, Y Zheng, X Zheng, Y Sun, X Yi, Z Wu, JM Lin - Lab on a Chip, 2023 - pubs.rsc.org
Multicellular tumor spheroids (MCTSs) are in vitro solid tumor models with physiological
relevance. To achieve robust process control, a MCTS fabrication method that combines cell …
relevance. To achieve robust process control, a MCTS fabrication method that combines cell …
Advances of three-dimensional (3D) culture systems for in vitro spermatogenesis
M Salem, F Khadivi, P Javanbakht… - Stem Cell Research & …, 2023 - Springer
The loss of germ cells and spermatogenic failure in non-obstructive azoospermia are
believed to be the main causes of male infertility. Laboratory studies have used in vitro …
believed to be the main causes of male infertility. Laboratory studies have used in vitro …
Thermo-Induced Coalescence of Dual Cores in Double Emulsions for Single-Cell RT-PCR
Single-cell reverse-transcription polymerase chain reaction (RT-PCR) has shown significant
promise for transcriptional profiling of heterogeneous cells. However, currently developed …
promise for transcriptional profiling of heterogeneous cells. However, currently developed …
Reflow-molded deep concave microwell arrays for robust and large-scale production of embryoid bodies
X Han, Q Zhang, H He, Q Zhao, G Li - Lab on a Chip, 2023 - pubs.rsc.org
Embryonic stem cell (ESC)-derived aggregates, called embryoid bodies (EBs), are powerful
in vitro models used to study human development and disease. However, the cost-effective …
in vitro models used to study human development and disease. However, the cost-effective …
3D cell cultures toward quantitative high-throughput drug screening
3D cell cultures are being utilized for drug discovery and development. However, there are
still challenges to implementing them generally in quantitative high-throughput screening …
still challenges to implementing them generally in quantitative high-throughput screening …
Flow cytometric printing of double emulsions into open droplet arrays
Delivery of double emulsions in air is crucial for their applications in mass spectrometry,
bioanalytics, and material synthesis. However, while methods have been developed to …
bioanalytics, and material synthesis. However, while methods have been developed to …
Microfabrication methods for 3D spheroids formation and their application in biomedical engineering
Three-dimensional cell culture systems offer greater understanding of the complex human
body structure than monolayer cell cultures. Spheroids, which are the most useful and …
body structure than monolayer cell cultures. Spheroids, which are the most useful and …