Mechanisms of HIV-1 neurotropism
R Dunfee, ER Thomas, PR Gorry, J Wang… - Current HIV …, 2006 - ingentaconnect.com
Human immunodeficiency virus type 1 (HIV) infects macrophages and microglia in the CNS
and frequently causes neurocognitive impairment. Although antiviral therapy generally …
and frequently causes neurocognitive impairment. Although antiviral therapy generally …
Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure
The initial step in target cell infection by human, and the closely related simian
immunodeficiency viruses (HIV and SIV, respectively) occurs with the binding of trimeric …
immunodeficiency viruses (HIV and SIV, respectively) occurs with the binding of trimeric …
An alteration of human immunodeficiency virus gp41 leads to reduced CCR5 dependence and CD4 independence
BM Taylor, JS Foulke, R Flinko, A Heredia… - Journal of …, 2008 - Am Soc Microbiol
Human immunodeficiency virus (HIV) type 1 infection requires functional interactions of the
viral surface (gp120) glycoprotein with cell surface CD4 and a chemokine coreceptor …
viral surface (gp120) glycoprotein with cell surface CD4 and a chemokine coreceptor …
[HTML][HTML] Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization
Insights into the process of HIV-1 neutralization may assist rational vaccine design. Here, we
compared antibody neutralization against the JR-FL primary isolate and trimer binding …
compared antibody neutralization against the JR-FL primary isolate and trimer binding …
Laser capture microdissection assessment of virus compartmentalization in the central nervous systems of macaques infected with neurovirulent simian …
Nonhuman primate-simian immunodeficiency virus (SIV) models are powerful tools for
studying the pathogenesis of human immunodeficiency virus type 1 (HIV-1) in the brain. Our …
studying the pathogenesis of human immunodeficiency virus type 1 (HIV-1) in the brain. Our …
Quaternary structures of HIV Env immunogen exhibit conformational vicissitudes and interface diminution elicited by ligand binding
CG Moscoso, Y Sun, S Poon, L Xing… - Proceedings of the …, 2011 - National Acad Sciences
The human immunodeficiency virus envelope protein is the key element mediating entry into
host cells. Conformational rearrangement of Env upon binding to the host CD4 receptor and …
host cells. Conformational rearrangement of Env upon binding to the host CD4 receptor and …
Cell-specific temporal infection of the brain in a simian immunodeficiency virus model of human immunodeficiency virus encephalitis
KA Thompson, JJ Varrone… - Journal of …, 2009 - Taylor & Francis
Increasing evidence supports early brain infection by human immunodeficiency virus (HIV).
Definitive temporal studies determining when and within which brain cells viral DNA is …
Definitive temporal studies determining when and within which brain cells viral DNA is …
Truncating the gp41 cytoplasmic tail of simian immunodeficiency virus decreases sensitivity to neutralizing antibodies without increasing the envelope content of …
E White, F Wu, E Chertova, J Bess, JD Roser… - Journal of …, 2018 - Am Soc Microbiol
An incomplete understanding of native human immunodeficiency virus (HIV) and simian
immunodeficiency virus (SIV) envelope glycoproteins (Envs) impedes the development of …
immunodeficiency virus (SIV) envelope glycoproteins (Envs) impedes the development of …
[PDF][PDF] An amphipathic sequence in the cytoplasmic tail of HIV-1 Env alters cell tropism and modulates viral receptor specificity
The human immunodeficiency virus type 1 (HIV-1) 92UG046 Env protein, obtained from a
CD4-independent HIV-1 primary isolate (Zerhouni et al., 2004), has the ability to initiate an …
CD4-independent HIV-1 primary isolate (Zerhouni et al., 2004), has the ability to initiate an …
Stability of a receptor-binding active human immunodeficiency virus type 1 recombinant gp140 trimer conferred by intermonomer disulfide bonding of the V3 loop …
J Billington, TP Hickling, GH Munro, C Halai… - Journal of …, 2007 - Am Soc Microbiol
Stable trimeric forms of human immunodeficiency virus recombinant gp140 (rgp140) are
important templates for determining the structure of the glycoprotein to assist in our …
important templates for determining the structure of the glycoprotein to assist in our …