Thrombosis, a major cause of deaths in this modern era responsible for 31% of all global
deaths reported by WHO in 2017, is due to the aggregation of fibrin in blood vessels which …

Cardiac disorders such as acute myocardial infarction, embolism and stroke are primarily
attributed to excessive fibrin accumulation in the blood vessels, usually consequential in …

Fibrinolytic enzymes are proteases responsible for cleavage of fibrin mesh in thrombus clots,
which are the primary causative agents in cardiovascular diseases. Developing safe …

Keratinase degrading Bacillus cereus was isolated from the halophilic environment in
Tamilnadu, India and keratinase production was optimized using wheat bran substrate. Of …

Enzyme therapies are attracting significant attention as thrombolytic drugs during the current
scenario owing to their great affinity, specificity, catalytic activity, and stability. Among various …

In this study, response surface methodology (RSM) was employed for the optimization of
bioprocess parameters for enhanced extracellular protease production by a native Bacillus …

The goal of this study was to develop a cheap and simple medium and to optimize
fermentation parameters for fibrinolytic enzyme production by Bacillus subtilis WR350. A low …

Fungi have a diverse spectrum of extracellular enzymes. In nature, extracellular enzymes
primarily serve to procure nutrients for the survival and growth of the fungi. Complex …

Background As a main drug for diseased thrombus, some clinically used thrombolytic agents
have various disadvantages, safer novel thrombolytic agents are of great demand. This …

Cardiovascular diseases (CVDs) are a global health problem and leading cause of death
worldwide. Thrombus formation, one of the CVDs, is essentially the formation of fibrin clots …