Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms

MC Liberman, SG Kujawa - Hearing research, 2017 - Elsevier
Common causes of hearing loss in humans-exposure to loud noise or ototoxic drugs and
aging-often damage sensory hair cells, reflected as elevated thresholds on the clinical …

Maladaptive plasticity in tinnitus—triggers, mechanisms and treatment

SE Shore, LE Roberts, B Langguth - Nature Reviews Neurology, 2016 - nature.com
Tinnitus is a phantom auditory sensation that reduces quality of life for millions of people
worldwide, and for which there is no medical cure. Most cases of tinnitus are associated with …

Toward a differential diagnosis of hidden hearing loss in humans

MC Liberman, MJ Epstein, SS Cleveland, H Wang… - PloS one, 2016 - journals.plos.org
Recent work suggests that hair cells are not the most vulnerable elements in the inner ear;
rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate …

Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss

SG Kujawa, MC Liberman - Hearing research, 2015 - Elsevier
The classic view of sensorineural hearing loss (SNHL) is that the “primary” targets are hair
cells, and that cochlear-nerve loss is “secondary” to hair cell degeneration. Our recent work …

Why is there no cure for tinnitus?

DJ McFerran, D Stockdale, R Holme… - Frontiers in …, 2019 - frontiersin.org
Tinnitus is unusual for such a common symptom in that there are few treatment options and
those that are available are aimed at reducing the impact rather than specifically addressing …

Evidence of cochlear neural degeneration in normal-hearing subjects with tinnitus

V Vasilkov, B Caswell-Midwinter, Y Zhao… - Scientific Reports, 2023 - nature.com
Tinnitus, reduced sound-level tolerance, and difficulties hearing in noisy environments are
the most common complaints associated with sensorineural hearing loss in adult …

Tinnitus: causes and clinical management

B Langguth, PM Kreuzer, T Kleinjung… - The Lancet …, 2013 - thelancet.com
Tinnitus is the perception of sound in the absence of a corresponding external acoustic
stimulus. With prevalence ranging from 10% to 15%, tinnitus is a common disorder. Many …

Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model

R Schaette, D McAlpine - Journal of Neuroscience, 2011 - Soc Neuroscience
Ever since Pliny the Elder coined the term tinnitus, the perception of sound in the absence of
an external sound source has remained enigmatic. Traditional theories assume that tinnitus …

Central gain control in tinnitus and hyperacusis

BD Auerbach, PV Rodrigues, RJ Salvi - Frontiers in neurology, 2014 - frontiersin.org
Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural
activity transmitted from the cochlea to the central auditory system. Despite a reduced …

[HTML][HTML] Cognitive behavioural therapy for tinnitus

T Fuller, R Cima, B Langguth, B Mazurek… - … of systematic reviews, 2020 - ncbi.nlm.nih.gov
Background Tinnitus affects up to 21% of the adult population with an estimated 1% to 3%
experiencing severe problems. Cognitive behavioural therapy (CBT) is a collection of …