Human endogenous retrovirus-K (HML-2): a comprehensive review
M Garcia-Montojo, T Doucet-O'Hare… - Critical reviews in …, 2018 - Taylor & Francis
The human genome contains a large number of retroviral elements acquired over the
process of evolution, some of which are specific to primates. However, as many of these are …
process of evolution, some of which are specific to primates. However, as many of these are …
[HTML][HTML] HERV envelope proteins: physiological role and pathogenic potential in cancer and autoimmunity
N Grandi, E Tramontano - Frontiers in microbiology, 2018 - frontiersin.org
Human endogenous retroviruses (HERVs) are relics of ancient infections accounting for
about the 8% of our genome. Despite their persistence in human DNA led to the …
about the 8% of our genome. Despite their persistence in human DNA led to the …
[HTML][HTML] HERV-K (HML-2), the best preserved family of HERVs: endogenization, expression, and implications in health and disease
O Hohn, K Hanke, N Bannert - Frontiers in oncology, 2013 - frontiersin.org
Retroviruses that have the ability to infect germ line cells can become an integral and
inherited part of the host genome. About 8% of the human chromosomal DNA consists of …
inherited part of the host genome. About 8% of the human chromosomal DNA consists of …
[HTML][HTML] Epigenetic control of human endogenous retrovirus expression: focus on regulation of long-terminal repeats (LTRs)
TP Hurst, G Magiorkinis - Viruses, 2017 - mdpi.com
Transposable elements, including endogenous retroviruses (ERVs), comprise almost 45%
of the human genome. This could represent a significant pathogenic burden but it is …
of the human genome. This could represent a significant pathogenic burden but it is …
[HTML][HTML] A deep learning approach reveals unexplored landscape of viral expression in cancer
About 15% of human cancer cases are attributed to viral infections. To date, virus expression
in tumor tissues has been mostly studied by aligning tumor RNA sequencing reads to …
in tumor tissues has been mostly studied by aligning tumor RNA sequencing reads to …
[HTML][HTML] Human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection
Direct in vivo investigation of human placenta trophoblast's susceptibility to SARS-CoV-2 is
challenging. Here we report that human trophoblast stem cells (hTSCs) and their derivatives …
challenging. Here we report that human trophoblast stem cells (hTSCs) and their derivatives …
Decidual T cells exhibit a highly differentiated phenotype and demonstrate potential fetal specificity and a strong transcriptional response to IFN
Immune tolerance during human pregnancy is maintained by a range of modifications to the
local and systemic maternal immune system. Lymphoid infiltration is seen at the implantation …
local and systemic maternal immune system. Lymphoid infiltration is seen at the implantation …
Expression and function of endogenous retroviruses in the placenta
J Denner - Apmis, 2016 - Wiley Online Library
Although the expression of endogenous retroviruses in the placenta of numerous species
was observed a long time ago, their physiological function during gestation was …
was observed a long time ago, their physiological function during gestation was …
[HTML][HTML] Cell-cell fusion mediated by viruses and HERV-derived fusogens in cancer initiation and progression
T Dittmar, J Weiler, T Luo, R Hass - Cancers, 2021 - mdpi.com
Simple Summary Even though it is known that (cancer) cells can fuse, it is still less
understood how (cancer) cells merge their plasma membranes, thereby giving rise to bi-and …
understood how (cancer) cells merge their plasma membranes, thereby giving rise to bi-and …
[HTML][HTML] Ancient adversary–HERV-K (HML-2) in cancer
E Dervan, DD Bhattacharyya, JD McAuliffe… - Frontiers in …, 2021 - frontiersin.org
Human endogenous retroviruses (HERV), ancient integrations of exogenous viruses, make
up 8% of our genome. Long thought of as mere vestigial genetic elements, evidence is now …
up 8% of our genome. Long thought of as mere vestigial genetic elements, evidence is now …