The anticancer activity of indazole compounds: a mini review
C Shang, Y Hou, T Meng, M Shi… - Current Topics in …, 2021 - ingentaconnect.com
The incidence and mortality of cancer continue to grow since the current medical treatments
often fail to produce a complete and durable tumor response and ultimately give rise to …
often fail to produce a complete and durable tumor response and ultimately give rise to …
Cellular and cell-free studies of catalytic DNA cleavage by ruthenium polypyridyl complexes containing redox-active intercalating ligands
C Griffith, AS Dayoub, T Jaranatne, N Alatrash… - Chemical …, 2017 - pubs.rsc.org
The ruthenium (II) polypyridyl complexes (RPCs),[(phen) 2Ru (tatpp)] 2+(32+) and [(phen)
2Ru (tatpp) Ru (phen) 2] 4+(44+) are shown to cleave DNA in cell-free studies in the …
2Ru (tatpp) Ru (phen) 2] 4+(44+) are shown to cleave DNA in cell-free studies in the …
Reactions of Ru (III)-drugs KP1019 and KP418 with guanine, 2′-deoxyguanosine and guanosine: a DFT study
Ruthenium (Ru)-based anticancer drugs are considered to be novel alternatives of platinum-
based drugs. They exhibit potent cytotoxicity against the cancer cells and hence are useful …
based drugs. They exhibit potent cytotoxicity against the cancer cells and hence are useful …
Effect of axial ligands on the mechanisms of action of Ru (III) complexes structurally similar to NAMI-A: a DFT study
PK Shah, PK Shukla - Structural Chemistry, 2020 - Springer
Although the mechanisms of action of Ru (III) anticancer drugs including NAMI-A and
KP1019 are not properly understood, it is reported that they are readily aquated in vivo …
KP1019 are not properly understood, it is reported that they are readily aquated in vivo …
Computational approach to unravel the role of hydrogen bonding in the interaction of NAMI-A with DNA nucleobases and nucleotides
D Das, MS Khan, G Barik, V Avasare… - The Journal of Physical …, 2018 - ACS Publications
Density functional theory method in combination with a continuum solvation model is used to
understand the role of hydrogen bonding in the interactions of tertiary nitrogen centers of …
understand the role of hydrogen bonding in the interactions of tertiary nitrogen centers of …
A theoretical characterization of mechanisms of action of osmium (III)-based drug Os-KP418: hydrolysis and its binding with guanine
The osmium (Os)-based complexes have recently attracted significant attention as a
potential anticancer drug due to their diverse cytotoxic activities and other remarkable …
potential anticancer drug due to their diverse cytotoxic activities and other remarkable …
Formation of bifunctional cross-linked products due to reaction of NAMI-A with DNA bases–a DFT study
PK Shah, PK Shukla - Structural Chemistry, 2022 - Springer
It is reported that NAMI-A and other Ru-anticancer complexes preferably bind with the N7
site of guanine and can also form DNA inter-strand cross-links. Therefore, in order to …
site of guanine and can also form DNA inter-strand cross-links. Therefore, in order to …
[图书][B] Cell-Free Studies of Catalytic DNA Cleavage by Ruthenium Polypyridyl Complexes (RPCS) Containing Redox-Active Intercalating Ligands, Enantiomeric …
CA Griffith - 2018 - search.proquest.com
Herein, we report the ruthenium (II) polypyridyl complexes (RPCs),[(phen) 2 Ru (tatpp)] 2+(3
2+) and [(phen) 2 Ru (tatpp) Ru (phen) 2] 4+(4 4+) are shown to cleave DNA in cell-free …
2+) and [(phen) 2 Ru (tatpp) Ru (phen) 2] 4+(4 4+) are shown to cleave DNA in cell-free …
Study of the Mechanism of Action for Ru (II) Polypyridyl Complexes as Potential Anticancer Agents
Y Sun - 2018 - uknowledge.uky.edu
Application of chemotherapeutic agents in current cancer treatment has been limited by
adverse effects as poor selectivity results in systemic toxicity; most chemotherapy …
adverse effects as poor selectivity results in systemic toxicity; most chemotherapy …