Altered microenvironmental stiffness is a hallmark of inflammation. It is sensed by the
mechanically activated cation channel Piezo1 in macrophages to induce subsequent …

Abstract Background and Aims Intestinal ultrasound [IUS] has been increasingly reported to
distinguish inflammatory or fibrotic intestinal stenosis in Crohn's disease [CD] patients …

Intestinal strictures remain one of the most intractable and common complications of Crohn's
disease (CD). Approximately 70% of CD patients will develop fibrotic strictures after 10 years …

Background and aims The stiffening of the extracellular matrix, and changes in its cellular
and molecular composition, have been reported in the pathogenesis of fibrosis. We analyze …

Piezo1, the mechanosensory ion channel, has attracted increasing attention for its essential
roles in various inflammatory responses and immune-related diseases. Although most of the …

Curcumin (Cur) exerts many benefits on the host, but its application is limited by its poor
bioavailability. In this study, composite polysaccharide microparticles loading Cur (Cur …

Monitoring the elasticity of soft biological tissues in the gastrointestinal (GI) tract with minimal
invasion holds promise for early diagnosis of intestinal fibrosis, colorectal cancer, and other …

Inflammatory bowel disease (IBD) comprises a group of relapsing, chronic diseases of the
gastrointestinal tract that, in addition to adults, can affect children and adolescents. To detect …

Background Gut stiffening caused by fibrosis plays a critical role in the progression of
inflammatory bowel disease (IBD) and colon cancer. Previous studies have characterized …

Strictures and abdominal pain often complicate Crohn's disease (CD). The primary aim was
to explore whether parameters obtained by preoperative contrast-enhanced (CE) …