The assessment of left ventricular (LV) diastolic function should be an integral part of a
routine examination, particularly in patients presenting with dyspnea or heart failure. About …

Objectives: The purpose of this study was to test the hypothesis that in heart failure with
normal ejection fraction (HFNEF) exercise limitation is due to combined systolic and diastolic …

802 produces rapid early diastolic flow that quickly propagates to the apex. Because the
diastolic intraventricular pressure gradient pulls blood to the apex, it can be considered a …

Despite Leonardo da Vinci's observation (circa 1511) that “the atria or filling chambers
contract together while the pumping chambers or ventricles are relaxing and vice versa,” the …

The giant protein titin is important for proper myofilament assembly and structure, as well as
the passive mechanical properties of the sarcomere. Within the sarcomeric I-band region of …

Background—Pressure overload resulting from aortic stenosis causes maladaptive
ventricular and vascular remodeling that can lead to pulmonary hypertension, heart failure …

Objectives: The incidence of heart failure continues to escalate with> 550,000 newly
diagnosed patients annually worldwide. More than half of the patients with heart failure have …

Viscosity is proposed to modulate diastolic function, but only limited understanding of the
source (s) of viscosity exists. In vitro experiments have shown that the proline-glutamic acid …

In cardiovascular research, relaxation and stiffness are calculated from pressure-volume
(PV) curves by separately fitting the data during the isovolumic and end-diastolic phases …

New Findings What is the topic of this review? This review focuses on how in vivo and
molecular measurements of cardiac passive stiffness can predict exercise tolerance and …