Abstract Polycomb group (PcG) and Trithorax group (TrxG) genes encode important
regulators of development and differentiation in metazoans. These two groups of genes …

Polycomb proteins form chromatin-modifying complexes that implement transcriptional
silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins …

Histone posttranslational modifications are key regulators of chromatin-associated
processes including gene expression, DNA replication and DNA repair. Monoubiquitinated …

Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous
developmental genes. To silence or activate gene expression, respectively, PcG and trxG …

Organization of chromatin by epigenetic mechanisms is essential for establishing and
maintaining cellular identity in developing and adult organisms. A key question that remains …

Alterations of chromatin structure have been shown to be crucial for response to cell
signaling and for programmed gene expression in development. Posttranslational histone …

▪ Abstract During the development of multicellular organisms, cells become different from
one another by changing their genetic program in response to transient stimuli. Long after …

Polycomb group complexes, which are known to regulate homeotic genes, have now been
found to control hundreds of other genes in mammals and insects. First believed to …

Polycomb group (PcG) protein complexes dynamically define cellular identity through the
regulation of key developmental genes. Important advances in the PcG field have come from …

Polycomb group (PcG) proteins maintain the transcriptional silence of target genes through
many cycles of cell division. Here, we provide evidence for the sequential binding of PcG …