The discovery of penicillin followed by streptomycin, tetracycline, cephalosporins and other
natural, semi-synthetic and synthetic antimicrobials completely revolutionized medicine by …

Methods These are the consensus statements and guideline of ASHP, IDSA, the Pediatric
Infectious Diseases Society (PIDS), and SIDP. Guideline panel composition consisted of …

Continuous infusion of vancomycin (CIV) and intermittent infusion of vancomycin (IIV) are
two major administration strategies in clinical settings. However, previous articles comparing …

Vancomycin is a fundamental antibiotic in the management of severe Gram‐positive
infections. Inappropriate vancomycin dosing is associated with therapeutic failure, bacterial …

Optimization of antimicrobial dosing in accordance with pharmacokinetics/
pharmacodynamics targets can improve survival and clinical cure. Dosing regimens for …

Objectives: Critically ill patients routinely receive vancomycin as empiric antibiotic therapy. A
continuous infusion administration strategy may be superior to intermittent infusion by …

The scope of TDM is broadening from the traditional focus on prevention of toxicity, to
include optimization of antibiotic exposure thereby improving patient outcomes. However …

Objective The clinical use of intermittent infusion of vancomycin (IIV) and continuous infusion
of vancomycin (CIV) is controversial. The aim of this study was to assess the effectiveness …

Vancomycin is a first-line antibiotic for empiric treatment of gram-positive infections in the
trauma intensive care unit. When dosed intermittently, difficulties arise from trough collection …

The elderly population can be divided into three distinct age groups: 65–74 years (young-
old), 75–84 years (middle-old), and 85+ years (old-old). Despite evidence of a shift in …