This comprehensive review surveys developments over the past decade in the field of
naphthalene diimides (NDIs). It explores their application toward: supramolecular chemistry; …

Abstract G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …

Aromaticity is one of the most widely applied concepts within chemistry. It plays a major role
in the rationalization of a range of chemical properties in the electronic ground state, despite …

The biological activity of Mannich bases, a structurally heterogeneous class of chemical
compounds that are generated from various substrates through the introduction of an …

Abstract ortho‐Quinone methides (o‐QMs) are emerging as highly useful intermediates, the
inherent reactivity of which can be used in linchpin reactions for the construction of complex …

Since its first observation in 1907, ortho-quinone methide (o-QM) has occupied a strategic
place within the framework of reactive intermediates in organic synthesis. In recent years, o …

Telomeres are present at the ends of all eukaryotic chromosomes. Human telomeres play an
important role in critical processes underlying genome stability, cancer, and aging, and their …

Ortho-quinone methides are important synthetic intermediates and widely implicated in
biological processes. In this Synopsis, recent advances concerning the synthesis and utility …

The folding of the single-stranded 3′ end of the human telomere into G-quadruplex
arrangements inhibits the overhang from hybridizing with the RNA template of telomerase …

Tetra-substituted naphthalene diimide (ND) derivatives with positively charged termini are
potent stabilizers of human telomeric and gene promoter DNA quadruplexes and inhibit the …