Myricetin bioactive effects: Moving from preclinical evidence to potential clinical applications

Y Taheri, HAR Suleria, N Martins, O Sytar… - … medicine and therapies, 2020 - Springer
Several flavonoids have been recognized as nutraceuticals, and myricetin is a good
example. Myricetin is commonly found in plants and their antimicrobial and antioxidant …

Myricetin: a multifunctional flavonol in biomedicine

G Agraharam, A Girigoswami… - Current pharmacology …, 2022 - Springer
Abstract Purpose of Reveiw The root cause of many diseases like CVD, cancer, and aging is
free radicals which exert their effect by interfering with different metabolic pathways. The …

[HTML][HTML] Flavonoids—Natural gifts to promote health and longevity

X Fan, Z Fan, Z Yang, T Huang, Y Tong… - International Journal of …, 2022 - mdpi.com
The aging of mammals is accompanied by the progressive atrophy of tissues and organs
and the accumulation of random damage to macromolecular DNA, protein, and lipids …

Flavonoids: Potential candidates for the treatment of neurodegenerative disorders

S Devi, V Kumar, SK Singh, AK Dubey, JJ Kim - Biomedicines, 2021 - mdpi.com
Neurodegenerative disorders, such as Parkinson's disease (PD), Alzheimer's disease (AD),
Amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD), are the most concerning …

Heat shock protein 70 (HSP70) induction: chaperonotherapy for neuroprotection after brain injury

JY Kim, S Barua, MY Huang, J Park, MA Yenari, JE Lee - Cells, 2020 - mdpi.com
The 70 kDa heat shock protein (HSP70) is a stress-inducible protein that has been shown to
protect the brain from various nervous system injuries. It allows cells to withstand potentially …

Anti-oxidative, anti-inflammatory and anti-apoptotic effects of flavonols: targeting Nrf2, NF-κB and p53 pathways in neurodegeneration

M Jazvinšćak Jembrek, N Oršolić, L Mandić, A Sadžak… - Antioxidants, 2021 - mdpi.com
Neurodegenerative diseases are one of the leading causes of disability and death
worldwide. Intracellular transduction pathways that end in the activation of specific …

[HTML][HTML] Mitochondria dysfunction and impaired response to oxidative stress promotes proteostasis disruption in aged human cells

D Trigo, A Nadais, A Carvalho, B Morgado, F Santos… - Mitochondrion, 2023 - Elsevier
The plastic architecture of the mitochondrial network and its dynamic structure play crucial
roles ensuring that varying energetic demands are rapidly met. Given the brain's high …

Pharmacological actions of myricetin in the nervous system: a comprehensive review of preclinical studies in animals and cell models

J Li, H Xiang, C Huang, J Lu - Frontiers in Pharmacology, 2021 - frontiersin.org
Myricetin is a natural flavonoid extracted from a variety of plants, such as medicinal herbs,
vegetables, berries, and tea leaves. A growing body of evidence has reported that myricetin …

Molecular Chaperones' Potential against Defective Proteostasis of Amyotrophic Lateral Sclerosis

S Kinger, AR Dubey, P Kumar, YA Jagtap… - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a neuronal degenerative condition identified via a
build-up of mutant aberrantly folded proteins. The native folding of polypeptides is mediated …

Zebrafish: a model deciphering the impact of flavonoids on neurodegenerative disorders

K Mhalhel, M Sicari, L Pansera, J Chen, M Levanti… - Cells, 2023 - mdpi.com
Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have
spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate …