G protein signaling in the parasite Entamoeba histolytica

DE Bosch, DP Siderovski - Experimental & molecular medicine, 2013 - nature.com
The parasite Entamoeba histolytica causes amebic colitis and systemic amebiasis. Among
the known amebic factors contributing to pathogenesis are signaling pathways involving …

The motility of Entamoeba histolytica: finding ways to understand intestinal amoebiasis

A Aguilar-Rojas, JC Olivo-Marin, N Guillen - Current opinion in …, 2016 - Elsevier
Highlights•Motility in E. histolytica is associated with rapid changes in cell
morphology.•Migration by E. histolytica varies according to the extracellular matrix density …

Phosphatidylinositol‐phosphates mediate cytoskeletal reorganization during phagocytosis via a unique modular protein consisting of RhoGEF/DH and FYVE domains …

K Nakada‐Tsukui, H Okada, BN Mitra… - Cellular …, 2009 - Wiley Online Library
To understand the roles of phosphoinositides [PtdIns] in phagocytosis of parasitic
eukaryotes, we examined the interaction of phosphatidylinositol‐3‐phosphate [PtdIns (3) P] …

A C2 domain protein kinase initiates phagocytosis in the protozoan parasite Entamoeba histolytica

Somlata, S Bhattacharya, A Bhattacharya - Nature communications, 2011 - nature.com
Phagocytosis is a process whereby particles are taken in by cells through mechanisms
superficially similar to those for endocytosis. It serves a wide range of functions, from …

Who needs a contractile actomyosin ring? The plethora of alternative ways to divide a protozoan parasite

TC Hammarton - Frontiers in Cellular and Infection Microbiology, 2019 - frontiersin.org
Cytokinesis, or the division of the cytoplasm, following the end of mitosis or meiosis, is
accomplished in animal cells, fungi, and amoebae, by the constriction of an actomyosin …

PAK thread from amoeba to mammals

A Kumar, PR Molli, SB Pakala… - Journal of cellular …, 2009 - Wiley Online Library
The p21‐activated kinases (PAKs) are signaling nodes that play a crucial role in cellular
processes including cell motility, differentiation, survival, gene transcription, and hormone …

Mechanisms of Adherence, Cytotoxicity and Phagocytosis Modulate the Pathogenesis of Entamoeba Histolytica

NCV Christy, WA Petri - Future microbiology, 2011 - Taylor & Francis
The unicellular parasite Entamoeba histolytica, the causative agent of the human disease
amebiasis, has traditionally been distinguished from its nonpathogenic cousin Entamoeba …

Live Cells Imaging and Comparative Phosphoproteomics Uncover Proteins from the Mechanobiome in Entamoeba histolytica

GD Jhingan, M Manich, JC Olivo-Marin… - International Journal of …, 2023 - mdpi.com
Entamoeba histolytica is a protozoan parasite and the causative agent of amoebiasis in
humans. This amoeba invades human tissues by taking advantage of its actin-rich …

A Proteomic and Cellular Analysis of Uropods in the Pathogen Entamoeba histolytica

J Marquay Markiewicz, S Syan, CC Hon… - PLoS neglected …, 2011 - journals.plos.org
Exposure of Entamoeba histolytica to specific ligands induces cell polarization via the
activation of signalling pathways and cytoskeletal elements. The process leads to formation …

Inter-Cellular Variation in DNA Content of Entamoeba histolytica Originates from Temporal and Spatial Uncoupling of Cytokinesis from the Nuclear Cycle

C Mukherjee, S Majumder, A Lohia - PLoS Neglected Tropical …, 2009 - journals.plos.org
Accumulation of multiple copies of the genome in a single nucleus and several nuclei in a
single cell has previously been noted in Entamoeba histolytica, contributing to the genetic …