Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria
and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been …

The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for
malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a …

Improvement of quality of life and survival of cancer patients will be greatly enhanced by the
development of highly effective drugs to selectively kill malignant cells. Artemisinin and its …

Simple Summary Renal cell carcinoma (RCC) is the most common kidney malignancy. Due
to development of therapy resistance, efficacy of conventional drugs such as sunitinib is …

Cancer chemotherapy is frequently hampered by drug resistance. Concepts to combine
anticancer drugs with different modes of action to avoid the development of resistance did …

Artemisinin contains an endoperoxide moiety that can react with iron to form cytotoxic free
radicals. Cancer cells contain significantly more intracellular free iron than normal cells and …

Tumour angiogenesis is the formation of new blood vessels to support the growth of a
tumour. This process is critical for tumour progression and metastasis, making it an attractive …

Sesquiterpene lactones are of considerable interest due to their potent bioactivities,
including cancer cell cytotoxicity and antineoplastic efficacy in in vivo studies. Among these …

The development of new efficient therapeutics for the treatment of malaria and cancer is an
important endeavor. Over the past 15 years, much attention has been paid to the synthesis …

Fibrosis is a pathological reparative process that can occur in most organs and is
responsible for nearly half of deaths in the developed world. Despite considerable research …