Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

While the root causes for individual neurodegenerative diseases are distinct, many shared
pathological features and mechanisms contribute to neurodegeneration across diseases …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Peripheral nerve repair and regeneration remains among the greatest challenges in tissue
engineering and regenerative medicine. Even though peripheral nerve injuries (PNIs) are …

Tissue engineered nerve grafts (TENGs) have emerged as a potential alternative to
autologous nerve grafts, the gold standard for peripheral nerve repair. Typically, TENGs are …

Following peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in
dorsal root ganglia (DRG) sensory neurons. Here we show that DRG neuron cell bodies …

Background Acute pain is a warning mechanism that exists to prevent tissue damage,
however pain can outlast its protective purpose and persist beyond injury, becoming …

Spinal cord injuries (SCI) often lead to persistent neurological dysfunction due to failure in
axon regeneration. Unfortunately, currently established treatments, such as direct drug …

Astrocytes are known to be critical regulators of neuronal function. However, relatively few
mediators of astrocyte to neuron communication have been identified. Recent …

Current treatment approaches toward spinal cord injuries (SCI) have mainly focused on
overcoming the inhibitory microenvironment that surrounds lesion sites. Unfortunately, the …