Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

Proteasomes are multienzyme complexes that maintain protein homeostasis (proteostasis)
and important cellular functions through the degradation of misfolded, redundant, and …

The proteasome has key roles in neuronal proteostasis, including the removal of misfolded
and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity …

Coxiella burnetii is the etiological agent of the zoonotic disease Q fever, which is featured by
its ability to replicate in acid vacuoles resembling the lysosomal network. One key virulence …

The proteasome system is a large and complex molecular machinery responsible for the
degradation of misfolded, damaged, and redundant cellular proteins. When proteasome …

Summary β-Amino residues are regarded as extremely rare features among ribosomal
products. They can be installed by a remarkable non-canonical enzymatic splicing process …

Despite annual increases in the incidence and prevalence of neurodegenerative diseases,
there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases …

The proteasome is a well-identified therapeutic target for cancer treatment. It acts as the
main protein degradation system in the cell and degrades key mediators of cell growth …

The abnormal accumulation of neurotoxic proteins is the typical hallmark of various age-
related neurodegenerative disorders (NDDs), including Alzheimer's disease, Parkinson's …

Loss of proteome fidelity leads to the accumulation of non-native protein aggregates and
oxidatively damaged species: hallmarks of an aged cell. These misfolded and aggregated …