The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

The year 2011 marks the centenary of Francis Peyton Rous's landmark experiments on an
avian cancer virus. Since then, seven human viruses have been found to cause 10–15% of …

Kaposi's sarcoma (KS) is the most common cancer in HIV-infected untreated individuals.
Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 …

Kaposi sarcoma (KS) herpesvirus (KSHV), also known as human herpesvirus 8, is the
causal agent of KS but is also pathogenetically related to several lymphoproliferative …

Infection of cells with DNA viruses triggers innate immune responses mediated by DNA
sensors. cGMP-AMP synthase (cGAS) is a key DNA sensor that produces the cyclic …

NF-κB transcription factors have been suspected to be involved in cancer development
since their discovery because of their kinship with the v-Rel oncogene product. Subsequent …

Oncoviruses are implicated in approximately 12% of all human cancers. A large number of
the world's population harbors at least one of these oncoviruses, but only a small proportion …

During their lifetime, cells encounter many life or death situations that challenge their very
own existence. Their survival depends on the interplay within a complex yet precisely …

The linkage of Kaposi sarcoma (KS) to infection by a novel human herpesvirus (Kaposi
sarcoma–associated herpesvirus [KSHV]) is one of the great successes of contemporary …

The transcription factor NF-κB is a tightly regulated positive mediator of T-and B-cell
development, proliferation, and survival. The controlled activity of NF-κB is required for the …