Genetic diseases seriously threaten human health and have always been one of the
refractory conditions facing humanity. Currently, gene therapy drugs such as siRNA, shRNA …

Tissue inhibitor of metalloproteinase 3 (TIMP3) is unique among the four TIMPs due to its
extracellular matrix (ECM)-binding property and broad range of inhibitory substrates that …

Adeno-associated viral vectors (AAVs) have become popular for gene therapy, given their
many advantages, including their reduced inflammatory profile compared with that of other …

Friedreich ataxia (FA) is currently an incurable inherited mitochondrial disease caused by
reduced levels of frataxin (FXN). Cardiac dysfunction is the main cause of premature death …

Manipulation of tumor microRNAs (miRNAs) may offer novel avenues for treatment of
cancer. However, development of safe, robust, non-viral delivery methods remains a main …

Discovered three decades ago, microRNAs (miRNAs) are now recognized as key players in
the pathophysiology of multiple human diseases, including those affecting the …

Aim: We aim to explore the regulatory mechanism of miR-328 and further develop miR-328-
loaded mesoporous silica nanoparticles (MSNs) and surface-decorated with polymerized …

Chronic heart failure (CHF) is a major contributor to cardiovascular disease and is the
leading cause of hospitalization for those over the age of 65, which is estimated to account …

Therapeutic angiogenesis induced by gene therapy is a promising approach to treat patients
suffering from severe coronary artery disease. In small experimental animals, adeno …

Myocardial ischemia/reperfusion injury (MIRI) is a prevalent condition associated with
numerous critical clinical conditions. miR‐322 has been implicated in MIRI through poorly …