Sagacity in antibody humanization for therapeutics, diagnostics and research purposes: considerations of antibody elements and their roles
The humanization of antibodies for therapeutics is a critical process that can determine the
success of antibody drug development. However, the science underpinning this process …
success of antibody drug development. However, the science underpinning this process …
Sagacious epitope selection for vaccines, and both antibody-based therapeutics and diagnostics: tips from virology and oncology
The target of an antibody plays a significant role in the success of antibody-based
therapeutics and diagnostics, and vaccine development. This importance is focused on the …
therapeutics and diagnostics, and vaccine development. This importance is focused on the …
Not all therapeutic antibody isotypes are equal: the case of IgM versus IgG in Pertuzumab and Trastuzumab
The therapeutic potential of immunoglobulin M (IgM) is of considerable interest in
immunotherapy due to its complement-activating and cell-agglutinating abilities …
immunotherapy due to its complement-activating and cell-agglutinating abilities …
Molecular insights of nickel binding to therapeutic antibodies as a possible new antibody superantigen
The binding of nickel by immune proteins can manifest as Type IV contact dermatitis (Ni-
specific T cells mediated) and less frequently as Type I hypersensitivity with both …
specific T cells mediated) and less frequently as Type I hypersensitivity with both …
[HTML][HTML] Role of the IgE variable heavy chain in FcεRIα and superantigen binding in allergy and immunotherapy
Background Variable heavy chain (VH) family frameworks (FWRs) have been reported to
affect antibody receptor and superantigen binding; however, such effects in IgE remain …
affect antibody receptor and superantigen binding; however, such effects in IgE remain …
Reviewing HIV-1 Gag mutations in protease inhibitors resistance: insights for possible novel Gag inhibitor designs
HIV protease inhibitors against the viral protease are often hampered by drug resistance
mutations in protease and in the viral substrate Gag. To overcome this drug resistance and …
mutations in protease and in the viral substrate Gag. To overcome this drug resistance and …
More than meets the kappa for antibody Superantigen protein L (PpL)
Immunoglobulin superantigens play an important role in affinity purification of antibodies
and the microbiota-immune axis at mucosal areas. Based on current understanding …
and the microbiota-immune axis at mucosal areas. Based on current understanding …
Essentially leading antibody production: an investigation of amino acids, myeloma, and natural V-region signal peptides in producing Pertuzumab and Trastuzumab …
Boosting the production of recombinant therapeutic antibodies is crucial in both academic
and industry settings. In this work, we investigated the usage of varying signal peptides by …
and industry settings. In this work, we investigated the usage of varying signal peptides by …
Variable-heavy (VH) families influencing IgA1&2 engagement to the antigen, FcαRI and superantigen proteins G, A, and L
Interest in IgA as an alternative antibody format has increased over the years with much
remaining to be investigated in relation to interactions with immune cells. Considering the …
remaining to be investigated in relation to interactions with immune cells. Considering the …
Augmenting recombinant antibody production in HEK293E cells: optimizing transfection and culture parameters
Background Optimizing recombinant antibody production is important for cost-effective
therapeutics and diagnostics. With impact on commercialization, higher productivity beyond …
therapeutics and diagnostics. With impact on commercialization, higher productivity beyond …