The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

Chemokines and chemokine receptors regulate multiple processes such morphogenesis,
angiogenesis and immune responses. Among the chemokine receptors, CXCR4 stands out …

Primary brain tumors, such as glioblastoma (GBM), are remarkably resistant to
immunotherapy, even though pre-clinical models suggest effectiveness. To understand this …

Exosomes are small endosome-derived extracellular vesicles implicated in cell–cell
communication and are secreted by living cells when multivesicular bodies (MVBs) fuse with …

T-cell trafficking at vascular sites has emerged as a key step in antitumour immunity.
Chemokines are credited with guiding the multistep recruitment of CD8+ T cells across …

Background As core units of organ tissues, cells of various types play their harmonious
rhythms to maintain the homeostasis of the human body. It is essential to identify the …

T cell autoreactivity is a hallmark of autoimmune diseases but can also benefit self-
maintenance and foster tissue repair. Here, we investigated whether heart-specific T cells …

The stromal cell-derived factor-1/CXCL12 chemokine engages the CXCR4 and CXCR7
receptors and regulates homeostatic and pathologic processes, including organogenesis …

For the past twenty years, chemokines have emerged as a family of critical mediators of cell
migration during immune surveillance, development, inflammation and cancer progression …

The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and
for promoting interactions with antigen-presenting cells (APCs). However, it is increasingly …