Recent knowledge on apoptosis has made it possible to devise novel approaches, which
exploit this process to treat cancer. In this review, we discuss in detail approaches to induce …

Apoptosis and necrosis are two morphologically distinct forms of cell death that are
important for maintaining of cellular homeostasis. Almost all agents can provoke either …

We have constructed a replication-deficient adenovirus encoding a nonphosphorylatable
Thr34→ Ala mutant of the apoptosis inhibitor survivin (pAd-T34A) to target tumor cell viability …

Despite the existence of a legislation regarding food contaminants, food safety control in
Serbia is a matter of great concern. This study investigates the radioactivity levels and heavy …

Autophagy is an alternative cell death pathway that is induced by mammalian target of
rapamycin (mTOR) inhibitors and up-regulated when apoptosis is defective. We investigated …

Prostaglandin E2 (PGE2) synthesis modulates the response to radiation injury in the mouse
intestinal epithelium through effects on crypt survival and apoptosis; however, the …

Background Bax is a pro‐apoptotic molecule that functions as a tumor suppressor and Bax
gene therapy has been examined for various cancers. Gene transfer by mRNA lipofection is …

The high mortality rates associated with ovarian cancer are largely due to a lack of highly
effective treatment options for advanced stage disease; a time when initial diagnosis most …

Concomitant treatment of radiotherapy and chemotherapy is widely used in cancer therapy.
The search for highly efficient radiochemotherapy drugs for tumor targeting therapy under …

Purpose: Bax plays an important role in the regulation of apoptosis induced by
chemotherapy and other stimuli. We therefore investigated the role of Bax in drug-induced …