Duchenne muscular dystrophy
Duchenne muscular dystrophy is a severe, progressive, muscle-wasting disease that leads
to difficulties with movement and, eventually, to the need for assisted ventilation and …
to difficulties with movement and, eventually, to the need for assisted ventilation and …
Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
ROS and diseases: Role in metabolism and energy supply
S Yang, G Lian - Molecular and cellular biochemistry, 2020 - Springer
Researches dedicated to reactive oxygen species (ROS) had been performed for decades,
yet the outcomes remain controversial. With the relentless effort of studies, researchers have …
yet the outcomes remain controversial. With the relentless effort of studies, researchers have …
Calcium signaling and reactive oxygen species in mitochondria
In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …
Endoplasmic reticulum–mitochondrial contactology: structure and signaling functions
G Csordás, D Weaver, G Hajnóczky - Trends in cell biology, 2018 - cell.com
Interorganellar contacts are increasingly recognized as central to the control of cellular
behavior. These contacts, which typically involve a small fraction of the endomembrane …
behavior. These contacts, which typically involve a small fraction of the endomembrane …
Impact of oxidative stress on the heart and vasculature: part 2 of a 3-part series
Vascular disease and heart failure impart an enormous burden in terms of global morbidity
and mortality. Although there are many different causes of cardiac and vascular disease …
and mortality. Although there are many different causes of cardiac and vascular disease …
[HTML][HTML] Calcium and ROS: A mutual interplay
A Görlach, K Bertram, S Hudecova, O Krizanova - Redox biology, 2015 - Elsevier
Calcium is an important second messenger involved in intra-and extracellular signaling
cascades and plays an essential role in cell life and death decisions. The Ca 2+ signaling …
cascades and plays an essential role in cell life and death decisions. The Ca 2+ signaling …
Molecular and cellular mechanisms of cardiovascular disorders in diabetes
MS Shah, M Brownlee - Circulation research, 2016 - Am Heart Assoc
The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …
Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target
Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …
essential cellular functions, including cardiac and skeletal muscle contraction. The …
The regulation and function of lactate dehydrogenase a: therapeutic potential in brain tumor
CJ Valvona, HL Fillmore, PB Nunn… - Brain …, 2016 - Wiley Online Library
There are over 120 types of brain tumor and approximately 45% of primary brain tumors are
gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a …
gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a …