The Kelch-like ECH-associated protein 1/nuclear factor erythroid-derived 2-like 2
(KEAP1/NRF2) pathway is well recognized as a key regulator of redox homeostasis …

Cellular homeostasis is continuously challenged by damage from reactive oxygen species
(ROS) and numerous reactive electrophiles. Human cells contain various protective systems …

Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their
exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan …

Structural resolution of protein interactions enables mechanistic and functional studies as
well as interpretation of disease variants. However, structural data is still missing for most …

Herein, an ultrasensitive and versatile electrochemical biosensor was developed through
the target-controlled capture and release of signal probe-loaded DNA nanotube for the …

In this work, an intelligent and versatile electrochemical biosensor was constructed to detect
two types of biomarkers by utilizing “off-on-off” switching. Firstly, human apurinic/apyrimidinic …

Cell-cell interactions instruct cell fate and function. These interactions are hijacked to
promote cancer development. Single-cell transcriptomics and spatial transcriptomics have …

This research paper examines the influence of spillovers between volatility of commodities
(including soft commodities, precious metals, industrial metals, along with energy) and …

Targeted protein degradation (TPD) is an emerging pharmacologic strategy. It relies on
small-molecule “degraders” that induce proximity of a component of an E3 ubiquitin ligase …

Despite significantly improved clinical outcomes in EGFR-mutant lung adenocarcinoma, all
patients develop acquired resistance and malignancy on the treatment of EGFR tyrosine …