Base editing is a powerful CRISPR-based technology for introducing precise substitutions
into the genome. This technology greatly advances mutagenesis possibilities in vivo …

Over the past decade, CRISPR/Cas-based gene editing has become a powerful tool for
generating mutations in a variety of model organisms, from Escherichia coli to zebrafish …

Advancements in CRISPR technology, particularly the development of base editors,
revolutionize genetic variant research. When combined with model organisms like zebrafish …

A synthetic biology toolkit, exploiting clustered regularly interspaced short palindromic
repeats (CRISPR) and modified CRISPR-associated protein (Cas) base-editors, was …

This is a spectacular moment for genetics to evolve in genome editing, which encompasses
the precise alteration of the cellular DNA sequences within various species. One of the most …

The necessity of a specific protospacer adjacent motif (PAM) greatly limited the editing
scope and the application range of Cas9-dependent base editors. Here, we showed that …

Appendage regeneration relies on the formation of blastema, a heterogeneous cellular
structure formed at the injury site. However, little is known about the early injury-activated …

The silkworm, which is considered a model invertebrate organism, was the first insect used
for silk production in human history and has been utilized extensively throughout its …

The gene editing technology represented by clustered rule-interspersed short palindromic
repeats (CRISPR)/Cas9 has developed as a common tool in the field of biotechnology …

CRISPR/Cas9 technology has increased the value of zebrafish for modeling human genetic
diseases, studying disease pathogenesis, and drug screening, but protospacer adjacent …