Deuterium in drug discovery: progress, opportunities and challenges

RMC Di Martino, BD Maxwell, T Pirali - Nature Reviews Drug Discovery, 2023 - nature.com
Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one
neutron to a molecule. Despite being a subtle change, this structural modification, known as …

Evidence-based guidelines for the pharmacological treatment of schizophrenia: updated recommendations from the British Association for Psychopharmacology

TRE Barnes, R Drake, C Paton… - Journal of …, 2020 - journals.sagepub.com
These updated guidelines from the British Association for Psychopharmacology replace the
original version published in 2011. They address the scope and targets of pharmacological …

[图书][B] The American Psychiatric Association practice guideline for the treatment of patients with schizophrenia

American Psychiatric Association - 2020 - books.google.com
The American Psychiatric Association Practice Guideline for the Treatment of Patients With
Schizophrenia seeks to reduce these substantial psychosocial and public health …

[HTML][HTML] The solute carrier transporters and the brain: Physiological and pharmacological implications

C Hu, L Tao, X Cao, L Chen - Asian journal of pharmaceutical sciences, 2020 - Elsevier
Solute carriers (SLCs) are the largest family of transmembrane transporters that determine
the exchange of various substances, including nutrients, ions, metabolites, and drugs across …

Antipsychotic-related movement disorders: drug-induced parkinsonism vs. tardive dyskinesia—key differences in pathophysiology and clinical management

KM Ward, L Citrome - Neurology and therapy, 2018 - Springer
Introduction Drug-induced parkinsonism (DIP) and tardive dyskinesia (TD) are stigmatizing
movement disorders associated with exposure to dopamine receptor blocking agents such …

Impact of deuterium substitution on the pharmacokinetics of pharmaceuticals

EM Russak, EM Bednarczyk - Annals of Pharmacotherapy, 2019 - journals.sagepub.com
Objective: Stable heavy isotopes of hydrogen, carbon, and other elements have been
incorporated into drug molecules, largely as tracers for quantitation during the drug …

Updating the recommendations for treatment of tardive syndromes: a systematic review of new evidence and practical treatment algorithm

R Bhidayasiri, O Jitkritsadakul, JH Friedman… - Journal of the …, 2018 - Elsevier
Background Management of tardive syndromes (TS) is challenging, with only a few
evidence-based therapeutic algorithms reported in the American Academy of Neurology …

Clinical risk factors for the development of tardive dyskinesia

M Solmi, G Pigato, JM Kane, CU Correll - Journal of the Neurological …, 2018 - Elsevier
Background Tardive dyskinesia (TD) is a severe condition that can affect almost 1 out of 4
patients on current or previous antipsychotic treatment, including both first-generation …

[HTML][HTML] Lower urinary tract symptoms in depression: a review

DJ Anderson, A Aucoin, CR Toups… - Health psychology …, 2023 - ncbi.nlm.nih.gov
Abstract Lower Urinary Tract Symptoms (LUTS) are frequently present in the general
population as patients age with approximately a third of individuals experiencing LUTS …

Pathophysiology, prognosis and treatment of tardive dyskinesia

H Takeuchi, Y Mori, Y Tsutsumi - Therapeutic advances in …, 2022 - journals.sagepub.com
Tardive dyskinesia (TD), a movement disorder associated with antipsychotics, most
frequently affects the lower face and jaw muscles, but can also affect walking, breathing and …