Tryptophan metabolism in health and disease
C Xue, G Li, Q Zheng, X Gu, Q Shi, Y Su, Q Chu… - Cell Metabolism, 2023 - cell.com
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …
From NASH to HCC: current concepts and future challenges
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …
[HTML][HTML] NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Hepatocellular carcinoma (HCC) can have viral or non-viral causes,,,–. Non-alcoholic
steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved …
steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved …
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
Abstract l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …
NAD+ homeostasis in health and disease
The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
Therapeutic potential of NAD-boosting molecules: the in vivo evidence
L Rajman, K Chwalek, DA Sinclair - Cell metabolism, 2018 - cell.com
Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …
well known for its role in redox reactions. More recently, it has emerged as a signaling …
NAD+ intermediates: the biology and therapeutic potential of NMN and NR
Research on the biology of NAD+ has been gaining momentum, providing many critical
insights into the pathogenesis of age-associated functional decline and diseases. In …
insights into the pathogenesis of age-associated functional decline and diseases. In …
[HTML][HTML] Role of NAD+ in regulating cellular and metabolic signaling pathways
Background Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in
every living cell, is involved in a myriad of metabolic processes associated with cellular …
every living cell, is involved in a myriad of metabolic processes associated with cellular …
Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice
KF Mills, S Yoshida, LR Stein, A Grozio, S Kubota… - Cell metabolism, 2016 - cell.com
NAD+ availability decreases with age and in certain disease conditions. Nicotinamide
mononucleotide (NMN), a key NAD+ intermediate, has been shown to enhance NAD+ …
mononucleotide (NMN), a key NAD+ intermediate, has been shown to enhance NAD+ …
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
MS Bonkowski, DA Sinclair - Nature reviews Molecular cell biology, 2016 - nature.com
Abstract The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-
dependent deacylases with remarkable abilities to prevent diseases and even reverse …
dependent deacylases with remarkable abilities to prevent diseases and even reverse …