Neuropeptides are a diverse class of neuronal signalling molecules that regulate
physiological processes and behaviour in animals. However, determining the relationships …

Chronic energy deficiency can impair the hypothalamic-pituitary-gonadal (HPG) axis and
lead to hypothalamic anovulation in underweight women. This review presents the …

The hypothalamic arcuate–median eminence complex (Arc-ME) controls energy balance,
fertility and growth through molecularly distinct cell types, many of which remain unknown …

Hibernating mammals actively lower their body temperature to reduce energy expenditure
when facing food scarcity. This ability to induce a hypometabolic state has evoked great …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

The hypothalamus is among the most phylogenetically conserved regions in the vertebrate
brain, reflecting its critical role in maintaining physiological and behavioural homeostasis. By …

Sleep and body temperature are tightly interconnected in mammals: warming up our body
helps to fall asleep and the body temperature in turn drops while falling asleep. The preoptic …

The initiation codon dictates that the translation initiation event exclusively begins with
methionine. We report here a new technology to reprogram the initiation event, where …

Anorexia nervosa (AN) is classically defined as a condition in which an abnormally low body
weight is associated with an intense fear of gaining weight and distorted cognitions …

Orexin signaling is essential for normal regulation of arousal and behavioral state control
and represents an attractive target for therapeutics combating insomnia. Alternatively termed …