A large proportion of androgens in men (40%), and the majority of estrogens in women (75%
before menopause and close to 100% after menopause), are synthesized in peripheral …

Dehydroepiandrosterone (DHEA) is not a hormone but it is a very important prohormone
secreted in large amounts by the adrenals in humans and other primates, but not in lower …

Exposure of humans to bisphenol A (BPA), a monomer in polycarbonate plastics and a
constituent of resins used in food packaging and dentistry, is significant. In this report …

The 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) isoenzymes are
responsible for the oxidation and isomerization of Δ5-3β-hydroxysteroid precursors into Δ4 …

Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are
implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids …

Ghrelin, the endogenous ligand for the GH-secretagogue receptor (GHS-R), is a recently
cloned peptide, primarily expressed in the stomach and hypothalamus, that acts at central …

To determine if neurosteroids (steroids synthesized in the brain) are produced by enzymes
found in steroidogenic tissues, we determined if mRNA for five steroidogenic enzymes could …

Increasing evidence suggests that mineralo-and glucocorticoids modulate cardiovascular
homeostasis via the effects of circulating components generated within the adrenals but also …

The amount of testosterone (T) secreted by Leydig cells is determined by a balance between
T biosynthetic and metabolizing enzyme activities. It has been established that 5α-androstan …

Conservation of sequences of subunits of mitochondrial complex I and their relationships
with other proteins Page 1 Biochimica et Biophysica Acta, 1140 (1992) 105-134 105 © 1992 …