Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Innate immunity is the first response to protect against pathogens and cellular insults.
Pattern recognition receptors sense pathogen-and damage-associated molecular patterns …

Cell death provides host defense and maintains homeostasis. Zα-containing molecules are
essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell …

Programmed cell death (PCD) is an essential part of organismal development and plays
fundamental roles in host defense against pathogens and the maintenance of homeostasis …

Abstract NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) is an intracellular
sensor that detects a broad range of microbial motifs, endogenous danger signals and …

ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …

COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute
lung damage associated with patient mortality. While multiple inflammatory cytokines are …

Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the
exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic …

The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally
identified as a nuclear factor that binds and activates the promoters of type I interferon …

Regulated cell death (RCD) triggered by innate immune activation is an important strategy
for host survival during pathogen invasion and perturbations of cellular homeostasis. There …