The present review offers an overview of nonclassical (eg, with no pre-or in situ activation of
a carboxylic acid partner) approaches for the construction of amide bonds. The review aims …

Understanding the mechanisms of chemical reactions, especially catalysis, has been an
important and active area of computational organic chemistry, and close collaborations …

A novel asymmetric radical aminotrifluoromethylation of alkenes has been developed for the
first time, providing straightforward access to densely functionalized CF3-containing …

Organolithium reagents are a vital tool in modern organic chemistry, enabling the synthesis
of carbon–carbon bonds. However, due to their high reactivity, low temperatures, inert …

The enantioselective and diastereoselective hydrogenation of N-heteroaromatic compounds
is an efficient strategy to access chirally enriched cyclic heterocycles, which often possess …

Thieme E-Journals - SynOpen / Full Text DE EN Home Products Journals Books Book Series
Service Library Service Help Contact Portal SynOpen Full-text search Full-text search Author …

Solvothermal and hydrothermal synthesis, that is, synthesis taking place in a solvent at
elevated temperature and pressure, is a powerful technique for the production of advanced …

We report a general palladium-catalyzed β-arylation of Boc-piperidines, which yields a
variety of valuable 3-arylpiperidines in a simple and direct manner. The β-vs. α-arylation …

Transition metal-catalyzed asymmetric hydrogenation of heteroaromatic compounds is
undoubtedly a straightforward and environmentally friendly method for the synthesis of a …

Methods that provide rapid access to new heterocyclic structures in biologically relevant
chemical space provide important opportunities in drug discovery. Here, a strategy is …