After cell entry, human immunodeficiency virus type 1 (HIV-1) replication involves reverse
transcription of the RNA genome, nuclear import of the subviral complex without nuclear …

A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential
structural component of a virion and facilitates many crucial life cycle steps through …

The HIV-1 capsid, composed of approximately 1,200 copies of the capsid protein, encases
genomic RNA alongside viral nucleocapsid, reverse transcriptase, and integrase proteins …

The delivery of the HIV-1 genome into the nucleus is an indispensable step in retroviral
infection of non-dividing cells, but the mechanism of HIV-1 nuclear import has been a …

HIV-1 encounters the hierarchically organized host chromatin to stably integrate and persist
in anatomically distinct latent reservoirs. The contribution of genome organization in HIV-1 …

Viruses are obligate parasites that rely on their host's cellular machinery for replication. To
facilitate their replication cycle, many viruses have been shown to remodel the cellular …

The capsid (CA) lattice of the HIV-1 core plays a key role during infection. From the moment
the core is released into the cytoplasm, it interacts with a range of cellular factors that …

Integration of retroviral reverse transcripts into the chromosomes of the cells that they infect
is required for efficient viral gene expression and the inheritance of viral genomes to …

In infectious HIV-1 particles, the capsid protein (CA) forms a cone-shaped shell called the
capsid, which encases the viral ribonucleoprotein complex (vRNP). Following cellular entry …