Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

Mucin type O‐glycosylation is one of the most diverse types of glycosylation, playing
essential roles in tissue development and homeostasis. In complex organisms, O‐GalNAc …

During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

Introduction: MUC16 is overexpressed in multiple cancers and plays an important role in
tumorigenicity and acquired resistance to therapy. Area covered: In this review, we describe …

Mucins are a large family of heavily O-glycosylated proteins that cover all mucosal surfaces
and constitute the major macromolecules in most body fluids. Mucins are primarily defined …

Cancer is the second most common cause of death in developed countries with
approximately 14 million newly diagnosed individuals and over 6 million cancer‐related …

Background Novel immunotherapies targeting cancer-associated truncated O-glycans Tn
(GalNAcα-Ser/Thr) and STn (Neu5Acα2–6GalNacα-Ser/Thr) are promising strategies for …

Background While the underlying causes of cancer are genetic modifications, changes in
cellular states mediate cancer development. Tumor cells display markedly changed …

Introduction: For decades, the role of glycans and glycoproteins in the progression of breast
cancer and other cancers have been evaluated. Through extensive studies focused on …

MUC16 (the cancer antigen CA125) is the most commonly used serum biomarker in
epithelial ovarian cancer, with increasing levels reflecting disease progression. It is a …