Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy

SB Reeder, I Cruite, G Hamilton… - Journal of magnetic …, 2011 - Wiley Online Library
Hepatic steatosis is characterized by abnormal and excessive accumulation of lipids within
hepatocytes. It is an important feature of diffuse liver disease, and the histological hallmark …

Fat-suppression techniques for 3-T MR imaging of the musculoskeletal system

F Del Grande, F Santini, DA Herzka, MR Aro… - Radiographics, 2014 - pubs.rsna.org
Fat suppression is an important technique in musculoskeletal imaging to improve the
visibility of bone-marrow lesions; evaluate fat in soft-tissue masses; optimize the contrast-to …

Multiomics study of nonalcoholic fatty liver disease

G Sveinbjornsson, MO Ulfarsson, RB Thorolfsdottir… - Nature …, 2022 - nature.com
Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed
a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and …

Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

Y Liu, N Basty, B Whitcher, JD Bell, EP Sorokin… - Elife, 2021 - elifesciences.org
Cardiometabolic diseases are an increasing global health burden. While socioeconomic,
environmental, behavioural, and genetic risk factors have been identified, a better …

[HTML][HTML] Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences

LM Cox, S Yamanishi, J Sohn, AV Alekseyenko… - Cell, 2014 - cell.com
Acquisition of the intestinal microbiota begins at birth, and a stable microbial community
develops from a succession of key organisms. Disruption of the microbiota during maturation …

Antibiotics in early life alter the murine colonic microbiome and adiposity

I Cho, S Yamanishi, L Cox, BA Methé, J Zavadil, K Li… - Nature, 2012 - nature.com
Antibiotics administered in low doses have been widely used as growth promoters in the
agricultural industry since the 1950s, yet the mechanisms for this effect are unclear. Because …

Quantifying fat replacement of muscle by quantitative MRI in muscular dystrophy

J Burakiewicz, CDJ Sinclair, D Fischer, GA Walter… - Journal of …, 2017 - Springer
The muscular dystrophies are rare orphan diseases, characterized by progressive muscle
weakness: the most common and well known is Duchenne muscular dystrophy which affects …

Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance

NF Schwenzer, F Springer, C Schraml, N Stefan… - Journal of …, 2009 - Elsevier
Hepatic steatosis is the most prevalent liver disorder in the developed world. It is closely
associated with features of metabolic syndrome, especially insulin resistance and obesity …

Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses

A Topiwala, C Wang, KP Ebmeier, S Burgess… - PLoS …, 2022 - journals.plos.org
Background Brain iron deposition has been linked to several neurodegenerative conditions
and reported in alcohol dependence. Whether iron accumulation occurs in moderate …

Nonlinear formulation of the magnetic field to source relationship for robust quantitative susceptibility mapping

T Liu, C Wisnieff, M Lou, W Chen… - Magnetic resonance …, 2013 - Wiley Online Library
Quantitative susceptibility mapping (QSM) opens the door for measuring tissue magnetic
susceptibility properties that may be important biomarkers, and QSM is becoming an …