Nanomedicine is currently focused on the design and development of nanocarriers that
enhance drug delivery to the brain to address unmet clinical needs for treating …

Abstract Treatment-resistant depression, defined as a failure of at least two oral
antidepressants of adequate dose and duration in the current episode, is a debilitating …

Introduction: Dissociative experiences are considered undesirable ketamine's adverse
events. However, they might be crucial for ketamine's antidepressant effects, at least in some …

Background Previous studies have demonstrated rapid-onset anti-suicidal ideation effects of
ketamine. This study aimed to compare the efficacy and duration of anti-suicidal thoughts …

Introduction and aims Treatment-resistant depression (TRD) occurs when at least two
different antidepressants, taken at the right dosage, for adequate period of time and with …

Background: Treatment-resistant depression (TRD) is defined as the failure of at least two
antidepressants in adequate doses and timing during a major depressive episode …

One in five people will likely suffer from major depressive disorder (MDD) during their life.
Thirty percent of those with MDD will experience Treatment Resistant Depression (TRD) …

Background: Posttraumatic stress disorder (PTSD) is a severe and frequent affection that is
highly comorbid to major depressive disorder. Comorbid PTSD and depression are usually …

Dementias and other neurologic diseases continue to increase in prevalence, and there
remain few truly effective treatments available to these patients. Intranasal drug delivery is …

First responders are vulnerable to the same psychiatric conditions and symptoms that affect
the general population. However, they are particularly vulnerable to certain conditions by …