A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements

AS Divakaruni, M Jastroch - Nature metabolism, 2022 - nature.com
Measurement of oxygen consumption is a powerful and uniquely informative experimental
technique. It can help identify mitochondrial mechanisms of action following pharmacologic …

[HTML][HTML] Progress in multicellular human cardiac organoids for clinical applications

H Kim, RD Kamm, G Vunjak-Novakovic, JC Wu - Cell Stem Cell, 2022 - cell.com
Advances in self-organizing cardiac organoids to recapitulate human cardiogenesis have
provided a powerful tool for unveiling human cardiac development, studying cardiovascular …

A guide to interrogating immunometabolism

K Voss, HS Hong, JE Bader, A Sugiura… - Nature Reviews …, 2021 - nature.com
The metabolic charts memorized in early biochemistry courses, and then later forgotten,
have come back to haunt many immunologists with new recognition of the importance of …

An integrated toolbox to profile macrophage immunometabolism

SGS Verberk, KE de Goede, FS Gorki… - Cell reports …, 2022 - cell.com
Macrophages are dynamic immune cells that can adopt several activation states.
Fundamental to these functional activation states is the regulation of cellular metabolic …

Genetically encoded ATP biosensors for direct monitoring of cellular ATP dynamics

D White III, Q Yang - Cells, 2022 - mdpi.com
Adenosine 5′-triphosphate, or ATP, is the primary molecule for storing and transferring
energy in cells. ATP is mainly produced via oxidative phosphorylation in mitochondria, and …

Advances in bioengineering pancreatic tumor-stroma physiomimetic Biomodels

MV Monteiro, LP Ferreira, M Rocha, VM Gaspar… - Biomaterials, 2022 - Elsevier
Pancreatic cancer exhibits a unique bioarchitecture and desmoplastic cancer-stoma
interplay that governs disease progression, multi-resistance, and metastasis. Emulating the …

Fluorescence-based detection of fatty acid β-oxidation in cells and tissues using quinone methide-releasing probes

S Uchinomiya, T Nagaura, M Weber… - Journal of the …, 2023 - ACS Publications
Detection of metabolic activity enables us to reveal the inherent metabolic state of cells and
elucidate mechanisms underlying cellular homeostasis and growth. However, a …

Molecular machinery and pathophysiology of mitochondrial dynamics

YH Chiu, SCA Lin, CH Kuo, CJ Li - Frontiers in Cell and …, 2021 - frontiersin.org
Mitochondria are double-membraned organelles that exhibit fluidity. They are the main site
of cellular aerobic respiration, providing energy for cell proliferation, migration, and survival; …

Organic dyes in contemporary medicinal chemistry and biomedicine. I. From the chromophore to the bioimaging/bioassay agent

Z Yaneva, D Ivanova, N Nikolova… - Biotechnology & …, 2022 - Taylor & Francis
The present review was provoked by the demand of a comprehensive overview on the
recent scientific achievements revealing new horizons for advanced applications of organic …

Mitochondria: at the crossroads between mechanobiology and cell metabolism

É Su, C Villard, J Manneville - Biology of the Cell, 2023 - Wiley Online Library
Metabolism and mechanics are two key facets of structural and functional processes in cells,
such as growth, proliferation, homeostasis and regeneration. Their reciprocal regulation has …