Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous
free radical whose predominant functions is that of a messenger through cGMP. In …

Nitric oxide (NO) is a short-lived, ubiquitous signaling molecule that affects numerous critical
functions in the body. There are markedly conflicting findings in the literature regarding the …

Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the
potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of …

Fluorouracil (5‐FU) is one of the most commonly used chemotherapeutic agents in colon
cancer treatment, but has a narrow therapeutic index limited by its toxicity. Melatonin exerts …

Diabetes is accompanied by several complications. Higher prevalence of cancers,
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …

The role of the three gasotransmitter systems–nitric oxide (NO), carbon monoxide (CO) and
hydrogen sulfide (H 2 S)–in cancer cells has not yet been studied simultaneously in the …

Eucalyptus oil (EO) used in traditional medicine continues to prove useful for aroma therapy
in respiratory ailments; however, there is a paucity of information on its mechanism of action …

Atherosclerosis is associated with inflammation in the arteries, which is a major cause of
heart attacks and strokes. Reducing the extent of local inflammation at atherosclerotic …

The recent characterization of the gut microbiome of traditional rural and foraging societies
allowed us to appreciate the essential co-adaptive role of the microbiome in complementing …

Cancer development is associated with abnormal proliferation, genetic instability, cell death
resistance, metabolic reprogramming, immunity evasion, and metastasis. These alterations …