Unraveling the role of antimicrobial peptides in insects

S Stączek, M Cytryńska… - International journal of …, 2023 - mdpi.com
Antimicrobial peptides (AMPs) are short, mainly positively charged, amphipathic molecules.
AMPs are important effectors of the immune response in insects with a broad spectrum of …

Nearly 30 years of animal models to study amyotrophic lateral sclerosis: a historical overview and future perspectives

T Bonifacino, RA Zerbo, M Balbi, C Torazza… - International journal of …, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …

Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants

L Ju, KM Glastad, L Sheng, J Gospocic, CJ Kingwell… - Cell, 2023 - cell.com
Here, we reveal an unanticipated role of the blood-brain barrier (BBB) in regulating complex
social behavior in ants. Using scRNA-seq, we find localization in the BBB of a key hormone …

Zebrafish and medaka: important animal models for human neurodegenerative diseases

J Wang, H Cao - International journal of molecular sciences, 2021 - mdpi.com
Animal models of human neurodegenerative disease have been investigated for several
decades. In recent years, zebrafish (Danio rerio) and medaka (Oryzias latipes) have become …

Animal models of neurodegenerative disease: Recent advances in fly highlight innovative approaches to drug discovery

JA Tello, HE Williams, RM Eppler… - Frontiers in molecular …, 2022 - frontiersin.org
Neurodegenerative diseases represent a formidable challenge to global health. As
advances in other areas of medicine grant healthy living into later decades of life, aging …

The power of Drosophila in modeling human disease mechanisms

EM Verheyen - Disease Models & Mechanisms, 2022 - journals.biologists.com
Six years ago, DMM launched a subject collection called 'Drosophila as a Disease Model'.
This collection features Review-type articles and original research that highlight the power of …

Phytochemicals of avocado residues as potential acetylcholinesterase inhibitors, antioxidants, and neuroprotective agents

GG da Silva, LPS Pimenta, JOF Melo, HOP Mendonça… - Molecules, 2022 - mdpi.com
Avocado (Persea americana) is a widely consumed fruit and a rich source of nutrients and
phytochemicals. Its industrial processing generates peels and seeds which represent 30 …

[HTML][HTML] Phytochemical screening and effect of Viscum album L. on monoamine oxidase A and B activity and serotonin, dopamine and serotonin receptor 5-HTR1A …

A Szurpnicka, AK Wrońska, K Bus, A Kozińska… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Viscum album L.(European mistletoe), a member of the
Santalaceae, is a hemiparasitic, evergreen shrub growing on deciduous and coniferous …

Towards improved screening of toxins for Parkinson's risk

L Shan, HJ Heusinkveld, KC Paul, S Hughes… - npj Parkinson's …, 2023 - nature.com
Parkinson's disease (PD) is a chronic, progressive and disabling neurodegenerative
disorder. The prevalence of PD has risen considerably over the past decades. A growing …

[HTML][HTML] Neuroprotective role of plumbagin on eye damage induced by high-sucrose diet in adult fruit fly Drosophila melanogaster

E Catalani, S Del Quondam, K Brunetti… - Biomedicine & …, 2023 - Elsevier
The natural compound plumbagin has a wide range of pharmacological and potential
therapeutic activities, although its role in neuroretina degeneration is unknown. Here we …