The inadequacy of a categorial approach to mental health diagnosis is now well-recognised,
with many authors, diagnostic manuals and funding bodies advocating a dimensional, trans …

Since the discovery of chlorpromazine (CPZ) in 1952, first-generation antipsychotics (FGAs)
have revolutionized psychiatric care in terms of facilitating discharge from hospital and …

Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

Background A huge and still growing mortality gap between people with severe mental
illness (SMI) and the general population exists. Physical illnesses, mainly cardiovascular …

Despite the long-standing belief in the analgesic properties of alcohol, experimental studies
have produced mixed results. This meta-analysis aimed to clarify whether alcohol produces …

Importance Although adults with schizophrenia have an increased risk of suicide, sample
size limitations of previous research have hindered characterizations of suicide risk across …

Although clinical studies suggest depressed patients may be more vulnerable to pain,
experimental research is equivocal. This meta-analysis aimed to clarify whether depression …

Schizophrenia research has traditionally focused almost exclusively on how the brain
interprets the outside world. However, our internal bodily milieu is also central to how we …

Childhood maltreatment represents a form of trauma capable of altering fundamental
neurobiological properties and negatively impacting neurodevelopmental processes. An …

Background Back pain (BP) is a leading cause of global disability. However, population-
based studies investigating its impact on mental health outcomes are lacking, particularly …