An automated single-molecule FRET platform for high-content, multiwell plate screening of biomolecular conformations and dynamics

A Hartmann, K Sreenivasa, M Schenkel… - Nature …, 2023 - nature.com
Single-molecule FRET (smFRET) has become a versatile tool for probing the structure and
functional dynamics of biomolecular systems, and is extensively used to address questions …

From Purification to Drug Screening: CFTR TM3/4 Mutants as Models for Membrane Protein Misfolding in Disease

MR Schenkel - 2024 - tud.qucosa.de
Abstract (DE) Membranproteine sind für die Zellphysiologie aller biologischen Domänen
von unbestreitbarer Bedeutung und ein Verlust ihrer Funktion, zB durch Mutationen in ihrer …

[PDF][PDF] Modulation of conformational space and dynamics of unfolded outer membrane proteins by periplasmic chaperones

N Chamachi - 2021 - core.ac.uk
Beta-barrel outer membrane proteins (OMPs) present on the outer membrane of
Gramnegative bacteria are vital to cell survival. Their biogenesis is a challenging process …