Advances in light microscopy for neuroscience

BA Wilt, LD Burns, ET Wei Ho, KK Ghosh… - Annual review of …, 2009 - annualreviews.org
Since the work of Golgi and Cajal, light microscopy has remained a key tool for
neuroscientists to observe cellular properties. Ongoing advances have enabled new …

Chemistry and the Worm: Caenorhabditis elegans as a Platform for Integrating Chemical and Biological Research

SE Hulme, GM Whitesides - Angewandte Chemie International …, 2011 - Wiley Online Library
This Review discusses the potential usefulness of the worm Caenorhabditis elegans as a
model organism for chemists interested in studying living systems. C. elegans, a 1 mm long …

Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans

SE Hulme, SS Shevkoplyas, AP McGuigan, J Apfeld… - Lab on a Chip, 2010 - pubs.rsc.org
This article describes the fabrication of a microfluidic device for the liquid culture of many
individual nematode worms (Caenorhabditis elegans) in separate chambers. Each chamber …

Femtosecond laser nanoaxotomy lab-on-a-chip for in vivo nerve regeneration studies

SX Guo, F Bourgeois, T Chokshi, NJ Durr, MA Hilliard… - Nature …, 2008 - nature.com
A thorough understanding of nerve regeneration in Caenorhabditis elegans requires
performing femtosecond laser nanoaxotomy while minimally affecting the worm. We present …

Long-term high-resolution imaging and culture of C. elegans in chip-gel hybrid microfluidic device for developmental studies

J Krajniak, H Lu - Lab on a Chip, 2010 - pubs.rsc.org
Developmental studies in multicellular model organisms such as Caernohabditis elegans
rely extensively on the ability to cultivate and image animals repeatedly at the cell or …

[HTML][HTML] Microfluidics as a tool for C. elegans research

A San-Miguel, H Lu - WormBook: The Online Review of C. elegans …, 2018 - ncbi.nlm.nih.gov
Microfluidics has emerged as a set of powerful tools that have greatly advanced some areas
of biological research, including research using C. elegans. The use of microfluidics has …

Microfluidics for the analysis of behavior, nerve regeneration, and neural cell biology in C. elegans

A Ben-Yakar, N Chronis, H Lu - Current opinion in neurobiology, 2009 - Elsevier
The nematode Caenorhabditis elegans is a widely adopted model organism for studying
various neurobiological processes at the molecular and cellular level in vivo. With a small …

Microfluidics-enabled phenotyping, imaging, and screening of multicellular organisms

MM Crane, K Chung, J Stirman, H Lu - Lab on a Chip, 2010 - pubs.rsc.org
This paper reviews the technologies that have been invented in the last few years on high-
throughput phenotyping, imaging, screening, and related techniques using microfluidics …

Droplet microfluidics for characterizing the neurotoxin-induced responses in individual Caenorhabditis elegans

W Shi, H Wen, Y Lu, Y Shi, B Lin, J Qin - Lab on a Chip, 2010 - pubs.rsc.org
A droplet-based microfluidic device integrated with a novel floatage-based trap array and a
tapered immobilization channel array was presented for characterizing the neurotoxin …

[HTML][HTML] Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans

BP Gupta, P Rezai - Micromachines, 2016 - mdpi.com
The nematode C. elegans (worm) is a small invertebrate animal widely used in studies
related to fundamental biological processes, disease modelling, and drug discovery. Due to …