[HTML][HTML] cAMP-PKA cascade: An outdated topic for depression?
F Gao, S Yang, J Wang, G Zhu - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Depression is a common neuropsychiatric disorder characterized by persistent depressed
mood and causes serious socioeconomic burden worldwide. Hyperactivity of the …
mood and causes serious socioeconomic burden worldwide. Hyperactivity of the …
cAMP-PKA signaling pathway and anxiety: where do we go next?
D Chen, J Wang, J Cao, G Zhu - Cellular Signalling, 2024 - Elsevier
Cyclic adenosine monophosphate (cAMP) is an intracellular second messenger that is
derived from the conversion of adenosine triphosphate catalysed by adenylyl cyclase (AC) …
derived from the conversion of adenosine triphosphate catalysed by adenylyl cyclase (AC) …
Melatonin alleviates traumatic brain injury‑induced anxiety‑like behaviors in rats: Roles of the protein kinase A/cAMP‑response element binding signaling pathway
LL Xie, SS Li, YJ Fan, MM Qi… - Experimental and …, 2022 - spandidos-publications.com
Melatonin is a hormone produced by the pineal gland. Given its capabilities of
neuroprotection and low neurotoxicity, melatonin could be a therapeutic strategy for …
neuroprotection and low neurotoxicity, melatonin could be a therapeutic strategy for …
[HTML][HTML] Epac: new emerging cAMP-binding protein
K Lee - BMB reports, 2021 - ncbi.nlm.nih.gov
The well-known second messenger cyclic adenosine monophosphate (cAMP) regulates the
morphology and physiology of neurons and thus higher cognitive brain functions. The …
morphology and physiology of neurons and thus higher cognitive brain functions. The …
Aberrant gene expression yet undiminished retinal ganglion cell genesis in iPSC-derived models of optic nerve hypoplasia
JG Aparicio, H Hopp, N Harutyunyan… - Ophthalmic …, 2024 - Taylor & Francis
Background Optic nerve hypoplasia (ONH), the leading congenital cause of permanent
blindness, is characterized by a retinal ganglion cell (RGC) deficit at birth. Multifactorial …
blindness, is characterized by a retinal ganglion cell (RGC) deficit at birth. Multifactorial …
Vitexin regulates Epac and NLRP3 and ameliorates chronic cerebral hypoperfusion injury
Q Zhang, Z Fan, W Xue, F Sun, H Zhu… - Canadian Journal of …, 2021 - cdnsciencepub.com
Chronic cerebral hypoperfusion (CCH), as a critical factor of chronic cerebrovascular
diseases, has greatly influenced the health of patients with vascular dementia. Vitexin, a …
diseases, has greatly influenced the health of patients with vascular dementia. Vitexin, a …
Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy
K Sivertsen Åsrud, L Pedersen, R Aesoy… - Scientific Reports, 2019 - nature.com
The exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2) are
expressed in a cell specific manner in the liver, but their biological functions in this tissue are …
expressed in a cell specific manner in the liver, but their biological functions in this tissue are …
Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions
K Sivertsen Åsrud, R Bjørnstad, R Kopperud… - Acta …, 2020 - Wiley Online Library
Abstract Aim The cAMP‐mediator Epac1 (RapGef3) has high renal expression. Preliminary
observations revealed increased diuresis in Epac1−/− mice. We hypothesized that Epac1 …
observations revealed increased diuresis in Epac1−/− mice. We hypothesized that Epac1 …
[PDF][PDF] 磷酸二酯酶4 抑制剂对阿尔茨海默病, 抑郁症及二者共病的潜在治疗作用及其机制研究进展
丛怡帆， 宋双双， 侯雪芹… - 中国药理学与毒理学杂志, 2022 - cjpt.magtechjournal.com
磷酸二酯酶4 (PDE4) 作为PDE 家族中数量最多的一类成员, 特异性水解细胞内第二信使环磷酸
腺苷(cAMP), 并参与多种生理功能的调节, 在中枢神经系统疾病的发生发展中发挥重要作用 …
腺苷(cAMP), 并参与多种生理功能的调节, 在中枢神经系统疾病的发生发展中发挥重要作用 …
Venlafaxine reduces the striatal il6/il10 ratio and increases hippocampal GR expression in female mice subjected to chronic social instability stress
A Labaka, E Gómez-Lazaro, O Goñi-Balentziaga… - Stress, 2021 - Taylor & Francis
Women are twice as likely as men to develop depression and antidepressant treatment is
more frequent in females. Moreover, neuroinflammatory changes related to affective …
more frequent in females. Moreover, neuroinflammatory changes related to affective …