Tissue engineering and its clinical application, regenerative medicine, are instructing
multiple approaches to aid in replacing bone loss after defects caused by trauma or cancer …

Maxillofacial bone defects caused by congenital malformations, trauma, tumors, and
inflammation can severely affect functions and aesthetics of maxillofacial region. Despite …

Stem cells can self-renew and produce different cell types, thus providing new strategies to
regenerate missing tissues and treat diseases. In the field of dentistry, adult mesenchymal …

Alveolar bone is the thickened ridge of jaw bone that supports teeth. It is subject to constant
occlusal force and pathogens invasion, and is therefore under active bone remodeling and …

Cellular strategies play an important role in bone tissue engineering and regenerative
medicine (BTE/RM). Variability in cell culture procedures (eg, cell types, cell isolation and …

As one of the first arriving immune cells after dental implantation, Mϕs own the abilities to
polarize into to a spectrum of diverse phenotypes, from “classically activated” M1 Mϕs to …

Tissue-engineered graft substitutes have shown great potential to treat large bone defects.
While we usually assume that therapeutic approaches developed for appendicular bone …

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been associated with long-
term oral or intravenous administration of nitrogen-containing bisphosphonates (BPs) …

Background Tissue-engineering strategies based on mesenchymal stem cells (MSCs) and
cell sheets have been widely used for periodontal tissue regeneration. However, given the …

Polymer-based composites are a group of biomaterials that exert synergic and combined
activity. There are multiple reported uses of these composites in multiple biomedical areas …