The hypoxia-inducible factor α-subunits (HIFα) are key transcription factors in the
mammalian response to oxygen deficiency. The HIFα regulation in response to hypoxia …

Abstract [Despite as a major inhibitor of urokinase (uPA), paradoxically,] Plasminogen
activator inhibitor-1 (PAI-1) has been validated to be highly expressed in various types of …

Fibrosis is characterized by excessive accumulation of extracellular matrix (ECM) in
basement membranes and interstitial tissues, resulting from increased synthesis or …

Overexpression of plasminogen activator inhibitor-1 (SER-PINE1, PAI-1), the major
physiological inhibitor of pericellular plasmin generation, is a significant causative factor in …

Accumulation of amyloid beta peptide (Aβ) in the brain is a pathological hallmark of
Alzheimer's disease (AD); the underlying mechanism, however, is not well understood. In …

The circadian clock and the hypoxia-signaling pathway are regulated by an integrated
interplay of positive and negative feedback limbs that incorporate energy homeostasis and …

Patients with chronic lymphocytic leukemia (CLL) have high plasma-levels of Wnt5a, which
can induce phosphorylation of ERK1/2 and enhance CLL-cell proliferation. Such effects …

The hypoxia-inducible factor-2α (HIF-2α) contributes to the vascular response to hypoxia.
Hypoxia inhibits prolyl hydroxylation of the N-terminal transactivation domain (N-TAD), thus …

AMPK plays significant roles in the modulation of metabolic reprogramming and viral
infection. However, the detailed mechanism by which AMPK affects viral infection is unclear …

Plasminogen activator inhibitor-1 (PAI-1) controls the regulation of the fibrinolytic system in
blood by inhibiting both urokinase-type and tissue-type plasminogen activators. Enhanced …