The vasculature plays a critical role in multiple physiologic and pathophysiologic processes.
A number of recent advances have led to renewed focus on the vasculature in the liver. In …

Evidence is increasing in hypertensive models for an inflammatory reaction in the
microcirculation with abnormal leukocyte counts and adhesion to the endothelium …

Carbon monoxide (CO) is emerging as an important and versatile mediator of physiological
processes to the extent that treatment of animals with exogenous CO gas has beneficial …

Transplantation of islets of Langerhans represents a viable therapeutic approach for the
treatment of type 1 diabetes. Unfortunately, transplanted islets are susceptible to allogeneic …

A direct role of carbon monoxide (CO), an effector-signaling molecule during heme
oxygenase-1 (HO-1) catalysis of heme, in the protection against hepatic …

Heme oxygenase-1 (HO-1) is an inducible stress protein the expression of which can be
markedly augmented in eukaryotes by a wide range of substances that cause a transient …

Background and Aims: Liver is a major organ for heme detoxification under disease
conditions, but its self-protective mechanisms against the toxicity are unknown. This study …

Heme oxygenase (HO) degrades protoheme IX by cleaving its-methene bridge into carbon
monoxide (CO), free divalent iron (Fe2), and biliverdin-IX. 1-3 The reaction uses …

Heme Oxygenase is the rate-limiting enzyme in the degradation of heme into carbon
monoxide (CO), iron and bilirubin. To date, three heme oxygenase isozymes have been …

Carbon monoxide (CO) is a stress‐inducible gas generated by heme oxygenase (HO)
eliciting adaptive responses against toxicants; however, mechanisms for its reception …