Virus-like particles (VLPs) are multiprotein structures that mimic the organization and
conformation of authentic native viruses but lack the viral genome, potentially yielding safer …

Viral infectious diseases threaten human health and global stability. Several vaccine
platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based …

The adaptation of adenoviruses as gene delivery tools has resulted in the development of
high-capacity adenoviral vectors (HC-AdVs), also known, helper-dependent or “gutless” …

Compared to traditional chromatography using resins in packed-bed columns, membrane
chromatography is a relatively new and immature bioseparation technology based on the …

Virus-like particles (VLPs) are self-assembled structures derived from viral antigens that
mimic the native architecture of viruses but lack the viral genome. VLPs have emerged as a …

Membrane systems play an essential role in the production of all biopharmaceuticals. This
includes initial clarification of cell culture fluid by both depth filtration and tangential flow …

Affinity chromatography is among the most powerful separation techniques, achieving the
finest separation with high yields even in the most challenging feed streams. Incorporating …

The downstream processing of virus particles for vaccination or gene therapy is becoming a
critical bottleneck as upstream titers keep improving. Moreover, the growing pressure to …

Manufacturing of cell culture-derived virus particles for vaccination and gene therapy is a
rapidly growing field in the biopharmaceutical industry. The process involves a number of …

Downstream processing of nanoplexes (viruses, virus-like particles, bacteriophages) is
characterized by complexity of the starting material, number of purification methods to …