The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Notch signaling is a conserved system of communication between adjacent cells,
influencing numerous cell fate decisions in the development of multicellular organisms …

We report a genome-wide association study of venous thromboembolism (VTE)
incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 …

The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally
active intracellular domain, on force to unfold a protective domain and permit proteolysis, on …

Protein glycosylation is a ubiquitous post-translational modification found in all domains of
life. Despite their significant complexity in animal systems, glycan structures have crucial …

Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

All photosynthetic multicellular Eukaryotes, including land plants and algae, have cells that
are surrounded by a dynamic, complex, carbohydrate-rich cell wall. The cell wall exerts …

Glycosylation is a very common modification of protein and lipid, and most glycosylation
reactions occur in the Golgi. Although the transfer of initial sugar (s) to glycoproteins or …

Alternatively activated “M2” macrophages are believed to function during late stages of
wound healing, behaving in an anti-inflammatory manner to mediate the resolution of the …